GWAS-related eQTLs across different cancer types
We identified 337,131 eQTLs that overlap with GWAS linkage disequilibrium (LD) regions (r² ≥ 0.5).
|
Cancer type
|
eQTL type
|
tagSNP
|
Gene position (hg19)
|
p-value
|
|||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| THCA | cis | rs867186 | 1 | rs6060246 | chr20:33701107 | PROCR | chr20:33758727-33765164:+ | -0.24 | -5.07 | 5.58E-7 | Anticoagulant levels;D-dimer levels;Protein C levels;Factor VII levels;Hemostatic factors and hematological phenotypes |
| THCA | cis | rs867186 | 1 | rs6060246 | chr20:33701107 | TRPC4AP | chr20:33590215-33680618:- | 0.21 | 3.5 | 0.000501 | Anticoagulant levels;D-dimer levels;Protein C levels;Factor VII levels;Hemostatic factors and hematological phenotypes |
| THCA | cis | rs6088813 | 1 | rs6060401 | chr20:34005214 | CEP250 | chr20:34042996-34099802:+ | -0.16 | -3.63 | 0.000318 | Height |
| THCA | cis | rs6088813 | 1 | rs6060401 | chr20:34005214 | CPNE1 | chr20:34213968-34262539:- | 0.31 | 6.03 | 3.35E-9 | Height |
| THCA | cis | rs6088813 | 1 | rs6060401 | chr20:34005214 | GDF5 | chr20:33897002-34042568:- | -0.18 | -3.82 | 0.000154 | Height |
| THCA | cis | rs6088813 | 1 | rs6060401 | chr20:34005214 | UQCC | chr20:33890383-33999833:- | 0.31 | 9.98 | 1.9E-21 | Height |
| THCA | cis | rs6088813 | 1 | rs6060402 | chr20:34005240 | CEP250 | chr20:34042996-34099802:+ | -0.16 | -3.5 | 0.000503 | Height |
| THCA | cis | rs6088813 | 1 | rs6060402 | chr20:34005240 | CPNE1 | chr20:34213968-34262539:- | 0.3 | 5.93 | 5.76E-9 | Height |
| THCA | cis | rs6088813 | 1 | rs6060402 | chr20:34005240 | GDF5 | chr20:33897002-34042568:- | -0.17 | -3.72 | 0.000221 | Height |
| THCA | cis | rs6088813 | 1 | rs6060402 | chr20:34005240 | UQCC | chr20:33890383-33999833:- | 0.32 | 10.15 | 4.58E-22 | Height |
| THCA | cis | rs3771570 | 1 | rs60604866 | chr2:242352257 | ANO7 | chr2:242127924-242164791:+ | 0.32 | 3.8 | 0.000164 | Prostate cancer |
| THCA | cis | rs3771570 | 1 | rs60604866 | chr2:242352257 | SEPT2 | chr2:242254723-242293439:+ | -0.31 | -4.57 | 6.31E-6 | Prostate cancer |
| THCA | cis | rs6087771 | 1 | rs6060599 | chr20:30257754 | COX4I2 | chr20:30225691-30232800:+ | 0.12 | 3.78 | 0.00018 | Subcortical brain region volumes |
| THCA | cis | rs6087771 | 1 | rs6060621 | chr20:30261562 | COX4I2 | chr20:30225691-30232800:+ | 0.12 | 3.85 | 0.000133 | Subcortical brain region volumes |
| THCA | cis | rs6087771 | 1 | rs6060716 | chr20:30274847 | COX4I2 | chr20:30225691-30232800:+ | 0.12 | 3.98 | 7.89E-5 | Subcortical brain region volumes |